The film tells the story of Hunter "Patch" Adams (portrayed by Robin Williams), a medical doctor who became famous for his unconventional approach to medicine. After a suicide attempt, Adams seeks psychiatric help and is institutionalized. During this time he is inspired to become a medical doctor, and discovers that he is able to forget his own problems by helping others. Two years later, he enrolls at Virginia Medical University (a fictitious school shot at the University of North Carolina at Chapel Hill campus) and is the oldest first year student. He questions the school's approach to medical care, and clashes with the school's Dean Walcott (played by Bob Gunton) because of his belief in the necessity of personal interaction with patients. Because of this and other incidents, including a prank during a medical conference, he is dismissed from the school, although he is later reinstated.

Patch is devastated by Corinne's death, and reconsiders his outlook and questions the goodness of humanity. However, he is able to recover and carry on his work.
Dismissed from the school for a second time because he ran a clinic and practiced medicine without a license, he must attend a hearing where it is decided whether he can graduate. Patch is able to convince the jury in a final speech that he did his best to help the people that came to him, stating that treating a disease of the body is a win-or-lose situation, but treating a person's spirit guarantees a win regardless of the outcome, even when it is death. In the end the jury accepts Patch's medical methods and does not prevent him from graduating.
Even at graduation, Patch cannot help but be a non-conformist. After handed his diploma, the man responsible for his expulsion states, "Well, I see you've finally decided to conform." Patch responds "more than you know," and bows to the audience, revealing he is nude under his gown. He then turns to the professors and bows to them, much to their dismay.
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